Background: Patients with autosomal dominant polycystic kidney disease (ADPKD) have an increased risk of\ncardiovascular morbidity and mortality. Impaired left ventricular (LV) global longitudinal strain (GLS) can be a sign of\nsubclinical cardiac dysfunction even in patients with otherwise preserved ejection fraction (EF). Transmitral early\nfilling velocity to early diastolic strain rate (E/SRe) is a novel measure of LV filling pressure, which is often affected\nearly in cardiac disease.\nMethods: A total of 110 ADPKD patients not on dialysis were included in this prospective study. All patients underwent\nan extensive echocardiographic examination including two-dimensional speckle tracking. GLS and strain rates\nwere measured. The distribution of GLS and E/SRe was determined and patient characteristics were compared\nby median levels of GLS (- 17.8%) and E/SRe (91.4 cm). Twenty healthy participants were included as control\ngroup������.
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